Carbon-ion pencil beam scanning for thoracic treatment – initiation report and dose metrics evaluation

Carbon-ion pencil beam scanning for thoracic treatment – initiation report and dose metrics evaluation

Carbon-ion beam scanning has not previously been used for moving tumor treatments. We have commenced respiratory-gated carbon-ion radiotherapy (CIRT) in the thoracic and abdominal regions under free-breathing conditions as a clinical trial. This study aimed to investigate this treatment in the lungs...

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Main Authors: Karube, Masataka, Mori, Shinichiro, Tsuji, Hiroshi, Yamamoto, Naoyoshi, Nakajima, Mio, Nakagawa, Keiichi, Kamada, Tadashi
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045082/
id pubmed-5045082
recordtype oai_dc
spelling pubmed-50450822016-10-03 Carbon-ion pencil beam scanning for thoracic treatment – initiation report and dose metrics evaluation Karube, Masataka Mori, Shinichiro Tsuji, Hiroshi Yamamoto, Naoyoshi Nakajima, Mio Nakagawa, Keiichi Kamada, Tadashi Technical Report Carbon-ion beam scanning has not previously been used for moving tumor treatments. We have commenced respiratory-gated carbon-ion radiotherapy (CIRT) in the thoracic and abdominal regions under free-breathing conditions as a clinical trial. This study aimed to investigate this treatment in the lungs in comparison with passive scattering CIRT. Five patients had thoracic tumors treated with carbon-ion scanned beams using respiratory gating. We analyzed the actual treatments and calculated passive scattering treatment plans based on the same planning CT. We evaluated tumor size until 3 months post treatment and each treatment plan regarding dose delivered to 95% of the clinical target volume (CTV-D95), mean lung dose, percentage of lung receiving at least 5 Gy (RBE) (Lung-V5), Lung-V10, Lung-V20, heart maximum dose (Dmax), esophagus Dmax, cord Dmax and skin Dmax. Obvious tumor deterioration was not observed up to 3 months post treatment. The dose evaluation metrics were similar item by item between respiratory-gated scanned CIRT and passive scattering CIRT. In conclusion, scanned beam CIRT provided treatments equivalent to passive scattering CIRT for thoracic tumors. Increased sample numbers and longer-term observation are needed. Oxford University Press 2016-09 2016-09-30 /pmc/articles/PMC5045082/ /pubmed/27380799 http://dx.doi.org/10.1093/jrr/rrw057 Text en © The Author 2016. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Karube, Masataka
Mori, Shinichiro
Tsuji, Hiroshi
Yamamoto, Naoyoshi
Nakajima, Mio
Nakagawa, Keiichi
Kamada, Tadashi
spellingShingle Karube, Masataka
Mori, Shinichiro
Tsuji, Hiroshi
Yamamoto, Naoyoshi
Nakajima, Mio
Nakagawa, Keiichi
Kamada, Tadashi
Carbon-ion pencil beam scanning for thoracic treatment – initiation report and dose metrics evaluation
author_facet Karube, Masataka
Mori, Shinichiro
Tsuji, Hiroshi
Yamamoto, Naoyoshi
Nakajima, Mio
Nakagawa, Keiichi
Kamada, Tadashi
author_sort Karube, Masataka
title Carbon-ion pencil beam scanning for thoracic treatment – initiation report and dose metrics evaluation
title_short Carbon-ion pencil beam scanning for thoracic treatment – initiation report and dose metrics evaluation
title_full Carbon-ion pencil beam scanning for thoracic treatment – initiation report and dose metrics evaluation
title_fullStr Carbon-ion pencil beam scanning for thoracic treatment – initiation report and dose metrics evaluation
title_full_unstemmed Carbon-ion pencil beam scanning for thoracic treatment – initiation report and dose metrics evaluation
title_sort carbon-ion pencil beam scanning for thoracic treatment – initiation report and dose metrics evaluation
description Carbon-ion beam scanning has not previously been used for moving tumor treatments. We have commenced respiratory-gated carbon-ion radiotherapy (CIRT) in the thoracic and abdominal regions under free-breathing conditions as a clinical trial. This study aimed to investigate this treatment in the lungs in comparison with passive scattering CIRT. Five patients had thoracic tumors treated with carbon-ion scanned beams using respiratory gating. We analyzed the actual treatments and calculated passive scattering treatment plans based on the same planning CT. We evaluated tumor size until 3 months post treatment and each treatment plan regarding dose delivered to 95% of the clinical target volume (CTV-D95), mean lung dose, percentage of lung receiving at least 5 Gy (RBE) (Lung-V5), Lung-V10, Lung-V20, heart maximum dose (Dmax), esophagus Dmax, cord Dmax and skin Dmax. Obvious tumor deterioration was not observed up to 3 months post treatment. The dose evaluation metrics were similar item by item between respiratory-gated scanned CIRT and passive scattering CIRT. In conclusion, scanned beam CIRT provided treatments equivalent to passive scattering CIRT for thoracic tumors. Increased sample numbers and longer-term observation are needed.
publisher Oxford University Press
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045082/
_version_ 1613668373155020800

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