New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy

New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy

Endocrine therapy using estrogen receptor-α (ER-α) antagonists for attenuating horm2one-driven cell proliferation is a major treatment modality for breast cancers. To exploit any DNA repair deficiencies associated with endocrine therapy, we investigated the functional and physical interactions of ER...

Full description

Bibliographic Details
Main Authors: Paranjpe, Ameya, Bailey, Nathan I., Konduri, Santhi, Bobustuc, George C., Ali-Osman, Francis, Yusuf, Mohd. A., Punganuru, Surendra R., Madala, Hanumantha Rao, Basak, Debasish, Mostofa, AGM, Srivenugopal, Kalkunte S.
Format: Online
Language:English
Published: Editorial Department of Journal of Biomedical Research 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044712/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044712/

Similar Items