Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer

Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer

Sustained expression of the oestrogen receptor alpha (ESR1) drives two-thirds of breast cancer and defines the ESR1-positive subtype. ESR1 engages enhancers upon oestrogen stimulation to establish an oncogenic expression program1. Somatic copy number alterations involving the ESR1 gene occur in appr...

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Bibliographic Details
Main Authors: Bailey, Swneke D., Desai, Kinjal, Kron, Ken J., Mazrooei, Parisa, Sinnott-Armstrong, Nicholas A., Treloar, Aislinn E., Dowar, Mark, Thu, Kelsie L., Cescon, David W., Silvester, Jennifer, Yang, S. Y. Cindy, Wu, Xue, Pezo, Rossanna C., Haibe-Kains, Benjamin, Mak, Tak W., Bedard, Philippe L., Pugh, Trevor J., Sallari, Richard C., Lupien, Mathieu
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042848/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042848/

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