Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer

Epithelial ovarian cancer (EOC) is one of the most lethal cancers in females. Cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) have been reported to be origin of primary and recurrent cancers and to be resistant to several treatments. In this study, we identified matrix metalloproteinase...

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Main Authors:	Mariya, Tasuku, Hirohashi, Yoshihiko, Torigoe, Toshihiko, Tabuchi, Yuta, Asano, Takuya, Saijo, Hiroshi, Kuroda, Takafumi, Yasuda, Kazuyo, Mizuuchi, Masahito, Saito, Tsuyoshi, Sato, Noriyuki
Format:	Online
Language:	English
Published:	Impact Journals LLC 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042016/

id	pubmed-5042016
recordtype	oai_dc
spelling	pubmed-50420162016-10-10 Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer Mariya, Tasuku Hirohashi, Yoshihiko Torigoe, Toshihiko Tabuchi, Yuta Asano, Takuya Saijo, Hiroshi Kuroda, Takafumi Yasuda, Kazuyo Mizuuchi, Masahito Saito, Tsuyoshi Sato, Noriyuki Research Paper Epithelial ovarian cancer (EOC) is one of the most lethal cancers in females. Cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) have been reported to be origin of primary and recurrent cancers and to be resistant to several treatments. In this study, we identified matrix metalloproteinase-10 (MMP10) is expressed in CSCs/CICs of EOC. An immunohistochemical study revealed that a high expression level of MMP10 is a marker for poor prognosis and platinum resistance in multivariate analysis. MMP10 gene overexpression experiments and MMP10 gene knockdown experiments using siRNAs revealed that MMP10 has a role in the maintenance of CSCs/CICs in EOC and resistance to platinum reagent. Furthermore, MMP10 activate canonical Wnt signaling by inhibiting noncanonical Wnt signaling ligand Wnt5a. Therefore, MMP10 is a novel marker for CSCs/CICs in EOC and that targeting MMP10 is a novel promising approach for chemotherapy-resistant CSCs/CICs in EOC. Impact Journals LLC 2016-04-08 /pmc/articles/PMC5042016/ /pubmed/27072580 http://dx.doi.org/10.18632/oncotarget.8645 Text en Copyright: © 2016 Mariya et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Mariya, Tasuku Hirohashi, Yoshihiko Torigoe, Toshihiko Tabuchi, Yuta Asano, Takuya Saijo, Hiroshi Kuroda, Takafumi Yasuda, Kazuyo Mizuuchi, Masahito Saito, Tsuyoshi Sato, Noriyuki
spellingShingle	Mariya, Tasuku Hirohashi, Yoshihiko Torigoe, Toshihiko Tabuchi, Yuta Asano, Takuya Saijo, Hiroshi Kuroda, Takafumi Yasuda, Kazuyo Mizuuchi, Masahito Saito, Tsuyoshi Sato, Noriyuki Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer
author_facet	Mariya, Tasuku Hirohashi, Yoshihiko Torigoe, Toshihiko Tabuchi, Yuta Asano, Takuya Saijo, Hiroshi Kuroda, Takafumi Yasuda, Kazuyo Mizuuchi, Masahito Saito, Tsuyoshi Sato, Noriyuki
author_sort	Mariya, Tasuku
title	Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer
title_short	Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer
title_full	Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer
title_fullStr	Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer
title_full_unstemmed	Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer
title_sort	matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical wnt signaling and can be a target of chemotherapy-resistant ovarian cancer
description	Epithelial ovarian cancer (EOC) is one of the most lethal cancers in females. Cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) have been reported to be origin of primary and recurrent cancers and to be resistant to several treatments. In this study, we identified matrix metalloproteinase-10 (MMP10) is expressed in CSCs/CICs of EOC. An immunohistochemical study revealed that a high expression level of MMP10 is a marker for poor prognosis and platinum resistance in multivariate analysis. MMP10 gene overexpression experiments and MMP10 gene knockdown experiments using siRNAs revealed that MMP10 has a role in the maintenance of CSCs/CICs in EOC and resistance to platinum reagent. Furthermore, MMP10 activate canonical Wnt signaling by inhibiting noncanonical Wnt signaling ligand Wnt5a. Therefore, MMP10 is a novel marker for CSCs/CICs in EOC and that targeting MMP10 is a novel promising approach for chemotherapy-resistant CSCs/CICs in EOC.
publisher	Impact Journals LLC
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042016/
_version_	1613665691557167104

Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer

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