Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis

To examine the relationship between cytotoxic T lymphocyte antigen-4 (CTLA-4) expression and esophageal carcinoma prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded primary tumor specimens from 158 patients with esophageal cancer. CTLA-4 was detected in the cytoplas...

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Main Authors:	Zhang, Xiao-Fei, Pan, Ke, Weng, De-Sheng, Chen, Chang-Long, Wang, Qi-Jing, Zhao, Jing-Jing, Pan, Qiu-Zhong, Liu, Qing, Jiang, Shan-Shan, Li, Yong-Qiang, Zhang, Hong-Xia, Xia, Jian-Chuan
Format:	Online
Language:	English
Published:	Impact Journals LLC 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042006/

id	pubmed-5042006
recordtype	oai_dc
spelling	pubmed-50420062016-10-10 Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis Zhang, Xiao-Fei Pan, Ke Weng, De-Sheng Chen, Chang-Long Wang, Qi-Jing Zhao, Jing-Jing Pan, Qiu-Zhong Liu, Qing Jiang, Shan-Shan Li, Yong-Qiang Zhang, Hong-Xia Xia, Jian-Chuan Research Paper To examine the relationship between cytotoxic T lymphocyte antigen-4 (CTLA-4) expression and esophageal carcinoma prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded primary tumor specimens from 158 patients with esophageal cancer. CTLA-4 was detected in the cytoplasm and cell membranes of esophageal cancer cells and in interstitial lymphocytes. In univariate analyses (log-rank), higher interstitial CTLA-4+ lymphocyte density and higher tumor CTLA-4 expression were associated with shorter overall survival (OS). After controlling for age and clinical stage, multivariate analysis (Cox) found that tumor CTLA-4 expression was an independent predictor of shorter OS (HR 2.016, P = 0.004). These results indicate that CTLA-4 expression in the tumor environment (both lymphocytes and tumor cells) is associated with poorer prognosis. In addition, CTLA-4 profiles may be useful for predicting the benefits and toxicity of CTLA-4 blockade in patients with esophageal carcinoma. Impact Journals LLC 2016-03-30 /pmc/articles/PMC5042006/ /pubmed/27050369 http://dx.doi.org/10.18632/oncotarget.8476 Text en Copyright: © 2016 Zhang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhang, Xiao-Fei Pan, Ke Weng, De-Sheng Chen, Chang-Long Wang, Qi-Jing Zhao, Jing-Jing Pan, Qiu-Zhong Liu, Qing Jiang, Shan-Shan Li, Yong-Qiang Zhang, Hong-Xia Xia, Jian-Chuan
spellingShingle	Zhang, Xiao-Fei Pan, Ke Weng, De-Sheng Chen, Chang-Long Wang, Qi-Jing Zhao, Jing-Jing Pan, Qiu-Zhong Liu, Qing Jiang, Shan-Shan Li, Yong-Qiang Zhang, Hong-Xia Xia, Jian-Chuan Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis
author_facet	Zhang, Xiao-Fei Pan, Ke Weng, De-Sheng Chen, Chang-Long Wang, Qi-Jing Zhao, Jing-Jing Pan, Qiu-Zhong Liu, Qing Jiang, Shan-Shan Li, Yong-Qiang Zhang, Hong-Xia Xia, Jian-Chuan
author_sort	Zhang, Xiao-Fei
title	Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis
title_short	Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis
title_full	Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis
title_fullStr	Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis
title_full_unstemmed	Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis
title_sort	cytotoxic t lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis
description	To examine the relationship between cytotoxic T lymphocyte antigen-4 (CTLA-4) expression and esophageal carcinoma prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded primary tumor specimens from 158 patients with esophageal cancer. CTLA-4 was detected in the cytoplasm and cell membranes of esophageal cancer cells and in interstitial lymphocytes. In univariate analyses (log-rank), higher interstitial CTLA-4+ lymphocyte density and higher tumor CTLA-4 expression were associated with shorter overall survival (OS). After controlling for age and clinical stage, multivariate analysis (Cox) found that tumor CTLA-4 expression was an independent predictor of shorter OS (HR 2.016, P = 0.004). These results indicate that CTLA-4 expression in the tumor environment (both lymphocytes and tumor cells) is associated with poorer prognosis. In addition, CTLA-4 profiles may be useful for predicting the benefits and toxicity of CTLA-4 blockade in patients with esophageal carcinoma.
publisher	Impact Journals LLC
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042006/
_version_	1613665678039973888

Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis

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