Multiple Roles of the Small GTPase Rab7
Rab7 is a small GTPase that belongs to the Rab family and controls transport to late endocytic compartments such as late endosomes and lysosomes. The mechanism of action of Rab7 in the late endocytic pathway has been extensively studied. Rab7 is fundamental for lysosomal biogenesis, positioning and...
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| Format: | Online |
| Language: | English |
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MDPI
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040976/ |
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pubmed-5040976 |
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pubmed-50409762016-10-05 Multiple Roles of the Small GTPase Rab7 Guerra, Flora Bucci, Cecilia Review Rab7 is a small GTPase that belongs to the Rab family and controls transport to late endocytic compartments such as late endosomes and lysosomes. The mechanism of action of Rab7 in the late endocytic pathway has been extensively studied. Rab7 is fundamental for lysosomal biogenesis, positioning and functions, and for trafficking and degradation of several signaling receptors, thus also having implications on signal transduction. Several Rab7 interacting proteins have being identified leading to the discovery of a number of different important functions, beside its established role in endocytosis. Furthermore, Rab7 has specific functions in neurons. This review highlights and discusses the role and the importance of Rab7 on different cellular pathways and processes. MDPI 2016-08-18 /pmc/articles/PMC5040976/ /pubmed/27548222 http://dx.doi.org/10.3390/cells5030034 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Guerra, Flora Bucci, Cecilia |
| spellingShingle |
Guerra, Flora Bucci, Cecilia Multiple Roles of the Small GTPase Rab7 |
| author_facet |
Guerra, Flora Bucci, Cecilia |
| author_sort |
Guerra, Flora |
| title |
Multiple Roles of the Small GTPase Rab7 |
| title_short |
Multiple Roles of the Small GTPase Rab7 |
| title_full |
Multiple Roles of the Small GTPase Rab7 |
| title_fullStr |
Multiple Roles of the Small GTPase Rab7 |
| title_full_unstemmed |
Multiple Roles of the Small GTPase Rab7 |
| title_sort |
multiple roles of the small gtpase rab7 |
| description |
Rab7 is a small GTPase that belongs to the Rab family and controls transport to late endocytic compartments such as late endosomes and lysosomes. The mechanism of action of Rab7 in the late endocytic pathway has been extensively studied. Rab7 is fundamental for lysosomal biogenesis, positioning and functions, and for trafficking and degradation of several signaling receptors, thus also having implications on signal transduction. Several Rab7 interacting proteins have being identified leading to the discovery of a number of different important functions, beside its established role in endocytosis. Furthermore, Rab7 has specific functions in neurons. This review highlights and discusses the role and the importance of Rab7 on different cellular pathways and processes. |
| publisher |
MDPI |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040976/ |
| _version_ |
1613664616673443840 |