HA Antibody-Mediated FcγRIIIa Activity Is Both Dependent on FcR Engagement and Interactions between HA and Sialic Acids

HA Antibody-Mediated FcγRIIIa Activity Is Both Dependent on FcR Engagement and Interactions between HA and Sialic Acids

Interactions with receptors for the Fc region of IgG (FcγRs) have been shown to contribute to the in vivo protection against influenza A viruses provided by broadly neutralizing antibodies (bnAbs) that bind to the viral hemagglutinin (HA) stem. In particular, Fc-mediated antibody-dependent cellular...

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Bibliographic Details
Main Authors: Cox, Freek, Kwaks, Ted, Brandenburg, Boerries, Koldijk, Martin H., Klaren, Vincent, Smal, Bastiaan, Korse, Hans J. W. M., Geelen, Eric, Tettero, Lisanne, Zuijdgeest, David, Stoop, Esther J. M., Saeland, Eirikur, Vogels, Ronald, Friesen, Robert H. E., Koudstaal, Wouter, Goudsmit, Jaap
Format: Online
Language:English
Published: Frontiers Media S.A. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040702/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040702/

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