Embryonic type Na+ channel β-subunit, SCN3B masks the disease phenotype of Brugada syndrome

Embryonic type Na+ channel β-subunit, SCN3B masks the disease phenotype of Brugada syndrome

SCN5A is abundant in heart and has a major role in INa. Loss-of-function mutation in SCN5A results in Brugada syndrome (BrS), which causes sudden death in adults. It remains unclear why disease phenotype does not manifest in the young even though mutated SCN5A is expressed in the young. The aim of t...

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Bibliographic Details
Main Authors: Okata, Shinichiro, Yuasa, Shinsuke, Suzuki, Tomoyuki, Ito, Shogo, Makita, Naomasa, Yoshida, Tetsu, Li, Min, Kurokawa, Junko, Seki, Tomohisa, Egashira, Toru, Aizawa, Yoshiyasu, Kodaira, Masaki, Motoda, Chikaaki, Yozu, Gakuto, Shimojima, Masaya, Hayashiji, Nozomi, Hashimoto, Hisayuki, Kuroda, Yusuke, Tanaka, Atsushi, Murata, Mitsushige, Aiba, Takeshi, Shimizu, Wataru, Horie, Minoru, Kamiya, Kaichiro, Furukawa, Tetsushi, Fukuda, Keiichi
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039759/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039759/

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