Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery

Gold nanorods (AuNR) have been intensively used in nanomedicine for cancer diagnostics and therapy, due to their excellent plasmonic photothermal properties. Tuning the size and aspect ratio of AuNR tailors the localized surface plasmon resonance (LSPR) in the NIR spectrum at which biological tissue...

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Main Authors:	Tong, Xiao, Wang, Zhantong, Sun, Xiaolian, Song, Jibin, Jacobson, Orit, Niu, Gang, Kiesewetter, Dale O., Chen, Xiaoyuan
Format:	Online
Language:	English
Published:	Ivyspring International Publisher 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039679/

id	pubmed-5039679
recordtype	oai_dc
spelling	pubmed-50396792016-10-03 Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery Tong, Xiao Wang, Zhantong Sun, Xiaolian Song, Jibin Jacobson, Orit Niu, Gang Kiesewetter, Dale O. Chen, Xiaoyuan Research Paper Gold nanorods (AuNR) have been intensively used in nanomedicine for cancer diagnostics and therapy, due to their excellent plasmonic photothermal properties. Tuning the size and aspect ratio of AuNR tailors the localized surface plasmon resonance (LSPR) in the NIR spectrum at which biological tissues are transparent, thus enables specific and effective treatment. The AuNR extravasates into tumor interstitium through enhanced permeation and retention (EPR) effect. Efficient AuNR based cancer therapy requires efficient AuNR tumor delivery. However, the size of AuNR can dramatically affect its blood circulation and tumor accumulation. Here we proposed for the first time a systematic framework to investigate the size-dependent kinetics of AuNRs during EPR mediated tumor delivery. By using 64Cu-labeled AuNRs with positron emission tomography (PET) and kinetic modeling, the in vivo uptake and kinetics of 64Cu-AuNR during its blood circulation, tumor accumulation and elimination were studied both in vitro and in vivo. The results of different sized AuNRs were compared and the optimum size of AuNR was suggested for EPR mediated tumor delivery. Our study provides a better understanding of the in vivo behavior of AuNR, which can help future design of nanomaterials for cancer imaging and therapy. Ivyspring International Publisher 2016-09-09 /pmc/articles/PMC5039679/ /pubmed/27698939 http://dx.doi.org/10.7150/thno.17098 Text en © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tong, Xiao Wang, Zhantong Sun, Xiaolian Song, Jibin Jacobson, Orit Niu, Gang Kiesewetter, Dale O. Chen, Xiaoyuan
spellingShingle	Tong, Xiao Wang, Zhantong Sun, Xiaolian Song, Jibin Jacobson, Orit Niu, Gang Kiesewetter, Dale O. Chen, Xiaoyuan Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery
author_facet	Tong, Xiao Wang, Zhantong Sun, Xiaolian Song, Jibin Jacobson, Orit Niu, Gang Kiesewetter, Dale O. Chen, Xiaoyuan
author_sort	Tong, Xiao
title	Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery
title_short	Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery
title_full	Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery
title_fullStr	Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery
title_full_unstemmed	Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery
title_sort	size dependent kinetics of gold nanorods in epr mediated tumor delivery
description	Gold nanorods (AuNR) have been intensively used in nanomedicine for cancer diagnostics and therapy, due to their excellent plasmonic photothermal properties. Tuning the size and aspect ratio of AuNR tailors the localized surface plasmon resonance (LSPR) in the NIR spectrum at which biological tissues are transparent, thus enables specific and effective treatment. The AuNR extravasates into tumor interstitium through enhanced permeation and retention (EPR) effect. Efficient AuNR based cancer therapy requires efficient AuNR tumor delivery. However, the size of AuNR can dramatically affect its blood circulation and tumor accumulation. Here we proposed for the first time a systematic framework to investigate the size-dependent kinetics of AuNRs during EPR mediated tumor delivery. By using 64Cu-labeled AuNRs with positron emission tomography (PET) and kinetic modeling, the in vivo uptake and kinetics of 64Cu-AuNR during its blood circulation, tumor accumulation and elimination were studied both in vitro and in vivo. The results of different sized AuNRs were compared and the optimum size of AuNR was suggested for EPR mediated tumor delivery. Our study provides a better understanding of the in vivo behavior of AuNR, which can help future design of nanomaterials for cancer imaging and therapy.
publisher	Ivyspring International Publisher
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039679/
_version_	1613663603504709632

Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery

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