Genetic Networks in Mouse Retinal Ganglion Cells
Retinal ganglion cells (RGCs) are the output neuron of the eye, transmitting visual information from the retina through the optic nerve to the brain. The importance of RGCs for vision is demonstrated in blinding diseases where RGCs are lost, such as in glaucoma or after optic nerve injury. In the pr...
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Frontiers Media S.A.
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039302/ |
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pubmed-50393022016-10-12 Genetic Networks in Mouse Retinal Ganglion Cells Struebing, Felix L. Lee, Richard K. Williams, Robert W. Geisert, Eldon E. Genetics Retinal ganglion cells (RGCs) are the output neuron of the eye, transmitting visual information from the retina through the optic nerve to the brain. The importance of RGCs for vision is demonstrated in blinding diseases where RGCs are lost, such as in glaucoma or after optic nerve injury. In the present study, we hypothesize that normal RGC function is transcriptionally regulated. To test our hypothesis, we examine large retinal expression microarray datasets from recombinant inbred mouse strains in GeneNetwork and define transcriptional networks of RGCs and their subtypes. Two major and functionally distinct transcriptional networks centering around Thy1 and Tubb3 (Class III beta-tubulin) were identified. Each network is independently regulated and modulated by unique genomic loci. Meta-analysis of publically available data confirms that RGC subtypes are differentially susceptible to death, with alpha-RGCs and intrinsically photosensitive RGCs (ipRGCs) being less sensitive to cell death than other RGC subtypes in a mouse model of glaucoma. Frontiers Media S.A. 2016-09-28 /pmc/articles/PMC5039302/ /pubmed/27733864 http://dx.doi.org/10.3389/fgene.2016.00169 Text en Copyright © 2016 Struebing, Lee, Williams and Geisert. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Struebing, Felix L. Lee, Richard K. Williams, Robert W. Geisert, Eldon E. |
| spellingShingle |
Struebing, Felix L. Lee, Richard K. Williams, Robert W. Geisert, Eldon E. Genetic Networks in Mouse Retinal Ganglion Cells |
| author_facet |
Struebing, Felix L. Lee, Richard K. Williams, Robert W. Geisert, Eldon E. |
| author_sort |
Struebing, Felix L. |
| title |
Genetic Networks in Mouse Retinal Ganglion Cells |
| title_short |
Genetic Networks in Mouse Retinal Ganglion Cells |
| title_full |
Genetic Networks in Mouse Retinal Ganglion Cells |
| title_fullStr |
Genetic Networks in Mouse Retinal Ganglion Cells |
| title_full_unstemmed |
Genetic Networks in Mouse Retinal Ganglion Cells |
| title_sort |
genetic networks in mouse retinal ganglion cells |
| description |
Retinal ganglion cells (RGCs) are the output neuron of the eye, transmitting visual information from the retina through the optic nerve to the brain. The importance of RGCs for vision is demonstrated in blinding diseases where RGCs are lost, such as in glaucoma or after optic nerve injury. In the present study, we hypothesize that normal RGC function is transcriptionally regulated. To test our hypothesis, we examine large retinal expression microarray datasets from recombinant inbred mouse strains in GeneNetwork and define transcriptional networks of RGCs and their subtypes. Two major and functionally distinct transcriptional networks centering around Thy1 and Tubb3 (Class III beta-tubulin) were identified. Each network is independently regulated and modulated by unique genomic loci. Meta-analysis of publically available data confirms that RGC subtypes are differentially susceptible to death, with alpha-RGCs and intrinsically photosensitive RGCs (ipRGCs) being less sensitive to cell death than other RGC subtypes in a mouse model of glaucoma. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039302/ |
| _version_ |
1613663170169143296 |