Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease

Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is one of the most important chronic liver diseases worldwide and has garnered increasing attention in recent decades. NAFLD is characterized by a wide range of liver changes, from simple steatosis to nonalcoholic steatohepatitis, cirrhosis, and hepatocellula...

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Main Authors: Chen, Guanliang, Ni, Yinhua, Nagata, Naoto, Xu, Liang, Ota, Tsuguhito
Format: Online
Language:English
Published: MDPI 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037659/
id pubmed-5037659
recordtype oai_dc
spelling pubmed-50376592016-09-29 Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease Chen, Guanliang Ni, Yinhua Nagata, Naoto Xu, Liang Ota, Tsuguhito Review Nonalcoholic fatty liver disease (NAFLD) is one of the most important chronic liver diseases worldwide and has garnered increasing attention in recent decades. NAFLD is characterized by a wide range of liver changes, from simple steatosis to nonalcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. The blurred pathogenesis of NAFLD is very complicated and involves lipid accumulation, insulin resistance, inflammation, and fibrogenesis. NAFLD is closely associated with complications such as obesity, diabetes, steatohepatitis, and liver fibrosis. During the progression of NAFLD, reactive oxygen species (ROS) are activated and induce oxidative stress. Recent attempts at establishing effective NAFLD therapy have identified potential micronutrient antioxidants that may reduce the accumulation of ROS and finally ameliorate the disease. In this review, we present the molecular mechanisms involved in the pathogenesis of NAFLD and introduce some dietary antioxidants that may be used to prevent or cure NAFLD, such as vitamin D, E, and astaxanthin. MDPI 2016-08-23 /pmc/articles/PMC5037659/ /pubmed/27563875 http://dx.doi.org/10.3390/ijms17091379 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Chen, Guanliang
Ni, Yinhua
Nagata, Naoto
Xu, Liang
Ota, Tsuguhito
spellingShingle Chen, Guanliang
Ni, Yinhua
Nagata, Naoto
Xu, Liang
Ota, Tsuguhito
Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease
author_facet Chen, Guanliang
Ni, Yinhua
Nagata, Naoto
Xu, Liang
Ota, Tsuguhito
author_sort Chen, Guanliang
title Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease
title_short Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease
title_full Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease
title_fullStr Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease
title_full_unstemmed Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease
title_sort micronutrient antioxidants and nonalcoholic fatty liver disease
description Nonalcoholic fatty liver disease (NAFLD) is one of the most important chronic liver diseases worldwide and has garnered increasing attention in recent decades. NAFLD is characterized by a wide range of liver changes, from simple steatosis to nonalcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. The blurred pathogenesis of NAFLD is very complicated and involves lipid accumulation, insulin resistance, inflammation, and fibrogenesis. NAFLD is closely associated with complications such as obesity, diabetes, steatohepatitis, and liver fibrosis. During the progression of NAFLD, reactive oxygen species (ROS) are activated and induce oxidative stress. Recent attempts at establishing effective NAFLD therapy have identified potential micronutrient antioxidants that may reduce the accumulation of ROS and finally ameliorate the disease. In this review, we present the molecular mechanisms involved in the pathogenesis of NAFLD and introduce some dietary antioxidants that may be used to prevent or cure NAFLD, such as vitamin D, E, and astaxanthin.
publisher MDPI
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037659/
_version_ 1613661968402481152

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