90K Glycoprotein Promotes Degradation of Mutant β-Catenin Lacking the ISGylation or Phosphorylation Sites in the N-terminus12
β-Catenin is a major transducer of the Wnt signaling pathway, which is aberrantly expressed in colorectal and other cancers. Previously, we showed that β-catenin is downregulated by the 90K glycoprotein via ISGylation-dependent degradation. However, the further mechanisms of β-catenin degradation by...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Neoplasia Press
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037265/ |