TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

•Pharmacologic inhibition of IP6K by TNP, at the onset of high fat feeding, decelerates initiation of DIO and insulin resistance in mice.•TNP, when treated to DIO mice, promotes weight loss and restores metabolic homeostasis.•TNP does not reduce high fat diet induced weight gain in IP6K1-KO mice.•TN...

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Bibliographic Details
Main Authors: Ghoshal, Sarbani, Zhu, Qingzhang, Asteian, Alice, Lin, Hua, Xu, Haifei, Ernst, Glen, Barrow, James C., Xu, Baoji, Cameron, Michael D., Kamenecka, Theodore M., Chakraborty, Anutosh
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034689/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034689/

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