α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

•Glucose stimulates α-MSH release from the pituitary.•Systemic α-MSH drives glucose disposal and thermogenesis in skeletal muscles.•α-MSH acts on MC5R expressed on skeletal muscles and activate cAMP-PKA pathway.•The combined treatment of nonselective or selective PDE 4 inhibitor and α-MSH ameliorate...

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Bibliographic Details
Main Authors: Enriori, Pablo J., Chen, Weiyi, Garcia-Rudaz, Maria C., Grayson, Bernadette E., Evans, Anne E., Comstock, Sarah M., Gebhardt, Ursel, Müller, Hermann L., Reinehr, Thomas, Henry, Belinda A., Brown, Russell D., Bruce, Clinton R., Simonds, Stephanie E., Litwak, Sara A., McGee, Sean L., Luquet, Serge, Martinez, Sarah, Jastroch, Martin, Tschöp, Matthias H., Watt, Matthew J., Clarke, Iain J., Roth, Christian L., Grove, Kevin L., Cowley, Michael A.
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034615/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034615/

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