Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression

Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression

In a cohort of Zambian heterosexual transmission pairs, the authors show that HIV-1–transmitted variants already exhibit a significant degree of preadaptation to the new host's HLA alleles, which, modulated by polymorphisms that decrease viral fitness, determines early set-point VL and the rate...

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Bibliographic Details
Main Authors: Mónaco, Daniela C., Dilernia, Dario A., Fiore-Gartland, Andrew, Yu, Tianwei, Prince, Jessica L., Dennis, Kristine K., Qin, Kai, Schaefer, Malinda, Claiborne, Daniel T., Kilembe, William, Tang, Jianming, Price, Matt A., Farmer, Paul, Gilmour, Jill, Bansal, Anju, Allen, Susan, Goepfert, Paul, Hunter, Eric
Format: Online
Language:English
Published: The Rockefeller University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030801/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030801/

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