An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2

The Hippo pathway represses YAP oncoprotein activity through phosphorylation by LATS kinases. Although variety of upstream components has been found to participate in the Hippo pathway, the existence and function of negative feedback has remained uncertain. We found that activated YAP, together with...

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Bibliographic Details
Main Authors: Park, Gun-Soo, Oh, Hyangyee, Kim, Minchul, Kim, Tackhoon, Johnson, Randy L., Irvine, Kenneth D., Lim, Dae-Sik
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029684/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029684/

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