Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration

Lung cancer is the leading cause of cancer-related deaths worldwide. Jin Fu Kang (JFK), an oral liquid prescription of Chinese herbal drugs, has been clinically available for the treatment of non-small cell lung cancer (NSCLC). Lymphangiogenesis is a primary event in the process of cancer developmen...

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Main Authors:	He, Hai-Lang, Wang, Dan, Tang, Jie, Zhou, Xian-Mei, Li, Jian-Xin, Xu, Ling
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028853/

id	pubmed-5028853
recordtype	oai_dc
spelling	pubmed-50288532016-10-03 Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration He, Hai-Lang Wang, Dan Tang, Jie Zhou, Xian-Mei Li, Jian-Xin Xu, Ling Research Article Lung cancer is the leading cause of cancer-related deaths worldwide. Jin Fu Kang (JFK), an oral liquid prescription of Chinese herbal drugs, has been clinically available for the treatment of non-small cell lung cancer (NSCLC). Lymphangiogenesis is a primary event in the process of cancer development and metastasis, and the formation and migration of lymphatic endothelial cells (LECs) play a key role in the lymphangiogenesis. To assess the activity of stromal cell-derived factor-1 (SDF-1) and the coeffect of SDF-1 and vascular endothelial growth factor-C (VEGF-C) on the formation and migration of LECs and clarify the inhibitory effects of JFK on the LECs, the LECs were differentiated from CD34+/VEGFR-3+ endothelial progenitor cells (EPCs), and JFK-containing serums were prepared from rats. SDF-1 and VEGF-C both induced the differentiation of CD34+/VEGFR-3+ EPCs towards LECs and enhanced the LECs migration. Couse of SDF-1 and VEGF-C displayed an additive effect on the LECs formation but not on their migration. JFK inhibited the formation and migration of LECs, and the inhibitory effects were most probably via regulation of the SDF-1/CXCR4 and VEGF-C/VEGFR-3 axes. The current finding suggested that JFK might inhibit NSCLC through antilymphangiogenesis and also provided a potential to discover antilymphangiogenesis agents from natural resources. Hindawi Publishing Corporation 2016 2016-09-06 /pmc/articles/PMC5028853/ /pubmed/27698675 http://dx.doi.org/10.1155/2016/3635209 Text en Copyright © 2016 Hai-Lang He et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	He, Hai-Lang Wang, Dan Tang, Jie Zhou, Xian-Mei Li, Jian-Xin Xu, Ling
spellingShingle	He, Hai-Lang Wang, Dan Tang, Jie Zhou, Xian-Mei Li, Jian-Xin Xu, Ling Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration
author_facet	He, Hai-Lang Wang, Dan Tang, Jie Zhou, Xian-Mei Li, Jian-Xin Xu, Ling
author_sort	He, Hai-Lang
title	Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration
title_short	Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration
title_full	Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration
title_fullStr	Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration
title_full_unstemmed	Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration
title_sort	jin fu kang oral liquid inhibits lymphatic endothelial cells formation and migration
description	Lung cancer is the leading cause of cancer-related deaths worldwide. Jin Fu Kang (JFK), an oral liquid prescription of Chinese herbal drugs, has been clinically available for the treatment of non-small cell lung cancer (NSCLC). Lymphangiogenesis is a primary event in the process of cancer development and metastasis, and the formation and migration of lymphatic endothelial cells (LECs) play a key role in the lymphangiogenesis. To assess the activity of stromal cell-derived factor-1 (SDF-1) and the coeffect of SDF-1 and vascular endothelial growth factor-C (VEGF-C) on the formation and migration of LECs and clarify the inhibitory effects of JFK on the LECs, the LECs were differentiated from CD34+/VEGFR-3+ endothelial progenitor cells (EPCs), and JFK-containing serums were prepared from rats. SDF-1 and VEGF-C both induced the differentiation of CD34+/VEGFR-3+ EPCs towards LECs and enhanced the LECs migration. Couse of SDF-1 and VEGF-C displayed an additive effect on the LECs formation but not on their migration. JFK inhibited the formation and migration of LECs, and the inhibitory effects were most probably via regulation of the SDF-1/CXCR4 and VEGF-C/VEGFR-3 axes. The current finding suggested that JFK might inhibit NSCLC through antilymphangiogenesis and also provided a potential to discover antilymphangiogenesis agents from natural resources.
publisher	Hindawi Publishing Corporation
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028853/
_version_	1613655335260651520

Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration

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