Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus

The current study was designed to reveal possible associations between the angiotensin-converting-enzyme (ACE) gene polymorphisms (rs4646994 and rs4341) with markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM) in a 4-year-long follow-up study. Five hundred and ninety-...

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Main Authors:	Merlo, S, Novák, J, Tkáčová, N, Nikolajević Starčević, J, Šantl Letonja, M, Makuc, J, Cokan Vujkovac, A, Letonja, J, Bregar, D, Zorc, M, Rojko, M, Mankoč, S, Kruzliak, P, Petrovič, D
Format:	Online
Language:	English
Published:	De Gruyter 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026267/

id	pubmed-5026267
recordtype	oai_dc
spelling	pubmed-50262672016-10-26 Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus Merlo, S Novák, J Tkáčová, N Nikolajević Starčević, J Šantl Letonja, M Makuc, J Cokan Vujkovac, A Letonja, J Bregar, D Zorc, M Rojko, M Mankoč, S Kruzliak, P Petrovič, D Original Article The current study was designed to reveal possible associations between the angiotensin-converting-enzyme (ACE) gene polymorphisms (rs4646994 and rs4341) with markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM) in a 4-year-long follow-up study. Five hundred and ninety-five T2DM subjects and 200 control subjects were enrolled. Genotyping of ACE polymorphisms was performed using KASPar assays, and ultrasound examinations were performed twice (at the enrollment and at follow-up). With regard to the progression of atherosclerosis in subjects with T2DM, statistically significant differences were demonstrated in the change of the sum of carotid plaques thickness for the rs4646994 polymorphism. We did not demonstrate an association between the tested polymorphisms (rs4646994 and rs4341) and either carotid intima media thickness (CIMT) or CIMT progression in a 3.8-year period. In our study, we demonstrated that subjects with T2DM with the DD genotype of the rs4646994 [ACE insertion/deletion (I/D)] polymorphism had faster progression of atherosclerosis in comparison to subjects with other genotypes. De Gruyter 2016-07-09 /pmc/articles/PMC5026267/ /pubmed/27785395 http://dx.doi.org/10.1515/bjmg-2015-0084 Text en © 2016 Walter de Gruyter GmbH, Berlin/Boston
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Merlo, S Novák, J Tkáčová, N Nikolajević Starčević, J Šantl Letonja, M Makuc, J Cokan Vujkovac, A Letonja, J Bregar, D Zorc, M Rojko, M Mankoč, S Kruzliak, P Petrovič, D
spellingShingle	Merlo, S Novák, J Tkáčová, N Nikolajević Starčević, J Šantl Letonja, M Makuc, J Cokan Vujkovac, A Letonja, J Bregar, D Zorc, M Rojko, M Mankoč, S Kruzliak, P Petrovič, D Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus
author_facet	Merlo, S Novák, J Tkáčová, N Nikolajević Starčević, J Šantl Letonja, M Makuc, J Cokan Vujkovac, A Letonja, J Bregar, D Zorc, M Rojko, M Mankoč, S Kruzliak, P Petrovič, D
author_sort	Merlo, S
title	Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus
title_short	Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus
title_full	Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus
title_fullStr	Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus
title_full_unstemmed	Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus
title_sort	association of the ace rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus
description	The current study was designed to reveal possible associations between the angiotensin-converting-enzyme (ACE) gene polymorphisms (rs4646994 and rs4341) with markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM) in a 4-year-long follow-up study. Five hundred and ninety-five T2DM subjects and 200 control subjects were enrolled. Genotyping of ACE polymorphisms was performed using KASPar assays, and ultrasound examinations were performed twice (at the enrollment and at follow-up). With regard to the progression of atherosclerosis in subjects with T2DM, statistically significant differences were demonstrated in the change of the sum of carotid plaques thickness for the rs4646994 polymorphism. We did not demonstrate an association between the tested polymorphisms (rs4646994 and rs4341) and either carotid intima media thickness (CIMT) or CIMT progression in a 3.8-year period. In our study, we demonstrated that subjects with T2DM with the DD genotype of the rs4646994 [ACE insertion/deletion (I/D)] polymorphism had faster progression of atherosclerosis in comparison to subjects with other genotypes.
publisher	De Gruyter
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026267/
_version_	1613653889722089472

Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus

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