Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity

Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity

The glucocorticoid receptor (GR) binds as a homodimer to genomic response elements, which have particular sequence and shape characteristics. Here we show that the nucleotides directly flanking the core-binding site, differ depending on the strength of GR-dependent activation of nearby genes. Our st...

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Bibliographic Details
Main Authors: Schöne, Stefanie, Jurk, Marcel, Helabad, Mahdi Bagherpoor, Dror, Iris, Lebars, Isabelle, Kieffer, Bruno, Imhof, Petra, Rohs, Remo, Vingron, Martin, Thomas-Chollier, Morgane, Meijsing, Sebastiaan H.
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025757/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025757/

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