SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration

SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration

Nicotine, a major chemical component of cigarettes, plays a pivotal role in the development of abdominal aortic aneurysm (AAA). c-Jun N-terminal kinase (JNK) has been demonstrated to participate in elastase-induced AAA. This study aimed to elucidate whether the JNK inhibitor SP600125 can attenuate n...

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Bibliographic Details
Main Authors: Guo, Zhen-Zhen, Cao, Qun-An, Li, Zong-Zhuang, Liu, Li-Ping, Zhang, Zhi, Zhu, Ya-Juan, Chu, Guang, Dai, Qiu-Yan
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023844/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023844/

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