Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands

Cystic neoplasms of the liver are divided into two types: mucinous cystic neoplasm and cystic intraductal papillary neoplasm of the bile duct. We herein report two cases of cystic and papillary neoplasm of the liver which differed from the abovementioned types. Case 1. A 70-year-old man. Radiologic...

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Main Authors:	Miyata, Takashi, Uesaka, Katsuhiko, Nakanuma, Yasuni
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021872/

id	pubmed-5021872
recordtype	oai_dc
spelling	pubmed-50218722016-09-21 Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands Miyata, Takashi Uesaka, Katsuhiko Nakanuma, Yasuni Case Report Cystic neoplasms of the liver are divided into two types: mucinous cystic neoplasm and cystic intraductal papillary neoplasm of the bile duct. We herein report two cases of cystic and papillary neoplasm of the liver which differed from the abovementioned types. Case 1. A 70-year-old man. Radiologically, a cystic tumor measuring 20 mm in diameter was found at the hepatic hilum. Right hepatectomy was performed under a diagnosis of intrahepatic cholangiocarcinoma (iCCA) based on the imaging findings. Case 2. A 70-year-old man. Radiologically, a cystic tumor measuring 60 mm in diameter was found at the hepatic hilum. Under a diagnosis of iCCA, left hepatic trisectionectomy was performed. In both cases, endoscopic retrograde cholangiography did not demonstrate communication between the cystic tumor and adjacent bile ducts. Pathologically, these two tumors were cystic neoplasms located at the hepatic hilum and were morphologically characterized by an intracystic papillary neoplasm composed of diffuse high-grade dysplasia and associated with an invasive carcinoma. Ovarian-like stroma was not found in the capsule of these tumors. Interestingly, there were peribiliary glands near these tumors, and MUC6 was expressed in these papillary neoplasms as well as in the peribiliary glands. These neoplasms might have arisen from the peribiliary glands. Hindawi Publishing Corporation 2016 2016-08-31 /pmc/articles/PMC5021872/ /pubmed/27656307 http://dx.doi.org/10.1155/2016/9130754 Text en Copyright © 2016 Takashi Miyata et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Miyata, Takashi Uesaka, Katsuhiko Nakanuma, Yasuni
spellingShingle	Miyata, Takashi Uesaka, Katsuhiko Nakanuma, Yasuni Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands
author_facet	Miyata, Takashi Uesaka, Katsuhiko Nakanuma, Yasuni
author_sort	Miyata, Takashi
title	Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands
title_short	Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands
title_full	Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands
title_fullStr	Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands
title_full_unstemmed	Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands
title_sort	cystic and papillary neoplasm at the hepatic hilum possibly originating in the peribiliary glands
description	Cystic neoplasms of the liver are divided into two types: mucinous cystic neoplasm and cystic intraductal papillary neoplasm of the bile duct. We herein report two cases of cystic and papillary neoplasm of the liver which differed from the abovementioned types. Case 1. A 70-year-old man. Radiologically, a cystic tumor measuring 20 mm in diameter was found at the hepatic hilum. Right hepatectomy was performed under a diagnosis of intrahepatic cholangiocarcinoma (iCCA) based on the imaging findings. Case 2. A 70-year-old man. Radiologically, a cystic tumor measuring 60 mm in diameter was found at the hepatic hilum. Under a diagnosis of iCCA, left hepatic trisectionectomy was performed. In both cases, endoscopic retrograde cholangiography did not demonstrate communication between the cystic tumor and adjacent bile ducts. Pathologically, these two tumors were cystic neoplasms located at the hepatic hilum and were morphologically characterized by an intracystic papillary neoplasm composed of diffuse high-grade dysplasia and associated with an invasive carcinoma. Ovarian-like stroma was not found in the capsule of these tumors. Interestingly, there were peribiliary glands near these tumors, and MUC6 was expressed in these papillary neoplasms as well as in the peribiliary glands. These neoplasms might have arisen from the peribiliary glands.
publisher	Hindawi Publishing Corporation
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021872/
_version_	1613650653186359296

Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands

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