An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion

An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion

•Loss of MPC activity in Drosophila leads to hyperglycemia.•Glucose-stimulated insulin secretion is impaired in Drosophila lacking MPC.•β-cell-specific MPC deletion in mice also results in impaired insulin secretion.•The MPC may be a sensor for glucose concentration in β-cells and couple pyruvate pr...

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Bibliographic Details
Main Authors: McCommis, Kyle S., Hodges, Wesley T., Bricker, Daniel K., Wisidagama, Dona R., Compan, Vincent, Remedi, Maria S., Thummel, Carl S., Finck, Brian N.
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021712/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021712/

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