Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice

Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice

•L. lactis can be engineered to produce Glucagon like peptide-1 (LL-GLP1).•L. lactis-derived GLP-1 induces insulin release in primary islets.•LL-GLP1 increases circulating GLP-1 levels in both chow and high fat diet fed mice.•LL-GLP1 improves glucose tolerance in both chow and high fat diet fed mice...

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Bibliographic Details
Main Authors: Arora, Tulika, Wegmann, Udo, Bobhate, Anup, Lee, Ying Shiuan, Greiner, Thomas U., Drucker, Daniel J., Narbad, Arjan, Bäckhed, Fredrik
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021674/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021674/

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