Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand

Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand

Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the d...

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Main Authors: Greene, Maxwell, Lai, Yongjie, Pajcini, Kostandin, Bailis, Will, Pear, Warren S., Lancaster, Eric
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021350/
id pubmed-5021350
recordtype oai_dc
spelling pubmed-50213502016-09-27 Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand Greene, Maxwell Lai, Yongjie Pajcini, Kostandin Bailis, Will Pear, Warren S. Lancaster, Eric Research Article Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown. Public Library of Science 2016-09-13 /pmc/articles/PMC5021350/ /pubmed/27622512 http://dx.doi.org/10.1371/journal.pone.0161157 Text en © 2016 Greene et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Greene, Maxwell
Lai, Yongjie
Pajcini, Kostandin
Bailis, Will
Pear, Warren S.
Lancaster, Eric
spellingShingle Greene, Maxwell
Lai, Yongjie
Pajcini, Kostandin
Bailis, Will
Pear, Warren S.
Lancaster, Eric
Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
author_facet Greene, Maxwell
Lai, Yongjie
Pajcini, Kostandin
Bailis, Will
Pear, Warren S.
Lancaster, Eric
author_sort Greene, Maxwell
title Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
title_short Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
title_full Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
title_fullStr Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
title_full_unstemmed Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
title_sort delta/notch-like egf-related receptor (dner) is not a notch ligand
description Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown.
publisher Public Library of Science
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021350/
_version_ 1613650327102291968

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