Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson’s Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study

Despite the clinical impact of non-motor symptoms (NMS) in Parkinson’s disease (PD), the characteristic NMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-naïve PD patients and compared NMS between PD subtypes. We enrolled 136 drug-naïve, early PD pat...

Full description

Bibliographic Details
Main Authors:	Mun, Jun Kyu, Youn, Jinyoung, Cho, Jin Whan, Oh, Eung-Seok, Kim, Ji Sun, Park, Suyeon, Jang, Wooyoung, Park, Jin Se, Koh, Seong-Beom, Lee, Jae Hyeok, Park, Hee Kyung, Kim, Han-Joon, Jeon, Beom S., Shin, Hae-Won, Choi, Sun-Ah, Kim, Sang Jin, Choi, Seong-Min, Park, Ji-Yun, Kim, Ji Young, Chung, Sun Ju, Lee, Chong Sik, Ahn, Tae-Beom, Kim, Won Chan, Kim, Hyun Sook, Cheon, Sang Myung, Kim, Jae Woo, Kim, Hee-Tae, Lee, Jee-Young, Kim, Eun-Joo, Kim, Jong-Min, Lee, Kwang Soo, Kim, Joong-Seok, Kim, Min-Jeong, Baik, Jong Sam, Park, Ki-Jong, Kim, Hee Jin, Park, Mee Young, Kang, Ji Hoon, Song, Sook Kun, Kim, Yong Duk, Yun, Ji Young, Lee, Ho-Won, Song, In-Uk, Sohn, Young H., Lee, Phil Hyu, Park, Jeong-Ho, Oh, Hyung Geun, Park, Kun Woo, Kwon, Do-Young
Format:	Online
Language:	English
Published:	Public Library of Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021347/

id	pubmed-5021347
recordtype	oai_dc
spelling	pubmed-50213472016-09-27 Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson’s Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study Mun, Jun Kyu Youn, Jinyoung Cho, Jin Whan Oh, Eung-Seok Kim, Ji Sun Park, Suyeon Jang, Wooyoung Park, Jin Se Koh, Seong-Beom Lee, Jae Hyeok Park, Hee Kyung Kim, Han-Joon Jeon, Beom S. Shin, Hae-Won Choi, Sun-Ah Kim, Sang Jin Choi, Seong-Min Park, Ji-Yun Kim, Ji Young Chung, Sun Ju Lee, Chong Sik Ahn, Tae-Beom Kim, Won Chan Kim, Hyun Sook Cheon, Sang Myung Kim, Jae Woo Kim, Hee-Tae Lee, Jee-Young Kim, Ji Sun Kim, Eun-Joo Kim, Jong-Min Lee, Kwang Soo Kim, Joong-Seok Kim, Min-Jeong Baik, Jong Sam Park, Ki-Jong Kim, Hee Jin Park, Mee Young Kang, Ji Hoon Song, Sook Kun Kim, Yong Duk Yun, Ji Young Lee, Ho-Won Song, In-Uk Sohn, Young H. Lee, Phil Hyu Park, Jeong-Ho Oh, Hyung Geun Park, Kun Woo Kwon, Do-Young Research Article Despite the clinical impact of non-motor symptoms (NMS) in Parkinson’s disease (PD), the characteristic NMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-naïve PD patients and compared NMS between PD subtypes. We enrolled 136 drug-naïve, early PD patients and 50 normal controls. All the enrolled PD patients were divided into tremor dominant (TD) and non-tremor dominant (NTD) subtypes. The Non-Motor Symptom Scale and scales for each NMS were completed. We compared NMS and the relationship of NMS with quality of life between normal controls and PD patients, and between the PD subtypes. Comparing with normal controls, PD patients complained of more NMS, especially mood/cognitive symptoms, gastrointestinal symptoms, unexplained pain, weight change, and change in taste or smell. Between the PD subtypes, the NTD subtype showed higher total NMS scale score and sub-score about weight change. Weight change was the characteristic NMS related to NTD subtype even after controlled other variables with logistic regression analysis. Even from the early stage, PD patients suffer from various NMS regardless of dopaminergic medication. Among the various NMS, weight change is the characteristic NMS associated with NTD subtype in PD patients. Public Library of Science 2016-09-13 /pmc/articles/PMC5021347/ /pubmed/27622838 http://dx.doi.org/10.1371/journal.pone.0162254 Text en © 2016 Mun et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Mun, Jun Kyu Youn, Jinyoung Cho, Jin Whan Oh, Eung-Seok Kim, Ji Sun Park, Suyeon Jang, Wooyoung Park, Jin Se Koh, Seong-Beom Lee, Jae Hyeok Park, Hee Kyung Kim, Han-Joon Jeon, Beom S. Shin, Hae-Won Choi, Sun-Ah Kim, Sang Jin Choi, Seong-Min Park, Ji-Yun Kim, Ji Young Chung, Sun Ju Lee, Chong Sik Ahn, Tae-Beom Kim, Won Chan Kim, Hyun Sook Cheon, Sang Myung Kim, Jae Woo Kim, Hee-Tae Lee, Jee-Young Kim, Ji Sun Kim, Eun-Joo Kim, Jong-Min Lee, Kwang Soo Kim, Joong-Seok Kim, Min-Jeong Baik, Jong Sam Park, Ki-Jong Kim, Hee Jin Park, Mee Young Kang, Ji Hoon Song, Sook Kun Kim, Yong Duk Yun, Ji Young Lee, Ho-Won Song, In-Uk Sohn, Young H. Lee, Phil Hyu Park, Jeong-Ho Oh, Hyung Geun Park, Kun Woo Kwon, Do-Young
spellingShingle	Mun, Jun Kyu Youn, Jinyoung Cho, Jin Whan Oh, Eung-Seok Kim, Ji Sun Park, Suyeon Jang, Wooyoung Park, Jin Se Koh, Seong-Beom Lee, Jae Hyeok Park, Hee Kyung Kim, Han-Joon Jeon, Beom S. Shin, Hae-Won Choi, Sun-Ah Kim, Sang Jin Choi, Seong-Min Park, Ji-Yun Kim, Ji Young Chung, Sun Ju Lee, Chong Sik Ahn, Tae-Beom Kim, Won Chan Kim, Hyun Sook Cheon, Sang Myung Kim, Jae Woo Kim, Hee-Tae Lee, Jee-Young Kim, Ji Sun Kim, Eun-Joo Kim, Jong-Min Lee, Kwang Soo Kim, Joong-Seok Kim, Min-Jeong Baik, Jong Sam Park, Ki-Jong Kim, Hee Jin Park, Mee Young Kang, Ji Hoon Song, Sook Kun Kim, Yong Duk Yun, Ji Young Lee, Ho-Won Song, In-Uk Sohn, Young H. Lee, Phil Hyu Park, Jeong-Ho Oh, Hyung Geun Park, Kun Woo Kwon, Do-Young Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson’s Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study
author_facet	Mun, Jun Kyu Youn, Jinyoung Cho, Jin Whan Oh, Eung-Seok Kim, Ji Sun Park, Suyeon Jang, Wooyoung Park, Jin Se Koh, Seong-Beom Lee, Jae Hyeok Park, Hee Kyung Kim, Han-Joon Jeon, Beom S. Shin, Hae-Won Choi, Sun-Ah Kim, Sang Jin Choi, Seong-Min Park, Ji-Yun Kim, Ji Young Chung, Sun Ju Lee, Chong Sik Ahn, Tae-Beom Kim, Won Chan Kim, Hyun Sook Cheon, Sang Myung Kim, Jae Woo Kim, Hee-Tae Lee, Jee-Young Kim, Ji Sun Kim, Eun-Joo Kim, Jong-Min Lee, Kwang Soo Kim, Joong-Seok Kim, Min-Jeong Baik, Jong Sam Park, Ki-Jong Kim, Hee Jin Park, Mee Young Kang, Ji Hoon Song, Sook Kun Kim, Yong Duk Yun, Ji Young Lee, Ho-Won Song, In-Uk Sohn, Young H. Lee, Phil Hyu Park, Jeong-Ho Oh, Hyung Geun Park, Kun Woo Kwon, Do-Young
author_sort	Mun, Jun Kyu
title	Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson’s Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study
title_short	Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson’s Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study
title_full	Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson’s Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study
title_fullStr	Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson’s Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study
title_full_unstemmed	Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson’s Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study
title_sort	weight change is a characteristic non-motor symptom in drug-naïve parkinson’s disease patients with non-tremor dominant subtype: a nation-wide observational study
description	Despite the clinical impact of non-motor symptoms (NMS) in Parkinson’s disease (PD), the characteristic NMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-naïve PD patients and compared NMS between PD subtypes. We enrolled 136 drug-naïve, early PD patients and 50 normal controls. All the enrolled PD patients were divided into tremor dominant (TD) and non-tremor dominant (NTD) subtypes. The Non-Motor Symptom Scale and scales for each NMS were completed. We compared NMS and the relationship of NMS with quality of life between normal controls and PD patients, and between the PD subtypes. Comparing with normal controls, PD patients complained of more NMS, especially mood/cognitive symptoms, gastrointestinal symptoms, unexplained pain, weight change, and change in taste or smell. Between the PD subtypes, the NTD subtype showed higher total NMS scale score and sub-score about weight change. Weight change was the characteristic NMS related to NTD subtype even after controlled other variables with logistic regression analysis. Even from the early stage, PD patients suffer from various NMS regardless of dopaminergic medication. Among the various NMS, weight change is the characteristic NMS associated with NTD subtype in PD patients.
publisher	Public Library of Science
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021347/
_version_	1613650324808007680

Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson’s Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study

Similar Items