Sources of Error in Mammalian Genetic Screens

Genetic screens are invaluable tools for dissection of biological phenomena. Optimization of such screens to enhance discovery of candidate genes and minimize false positives is thus a critical aim. Here, we report several sources of error common to pooled genetic screening techniques used in mammal...

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Bibliographic Details
Main Authors: Sack, Laura Magill, Davoli, Teresa, Xu, Qikai, Li, Mamie Z., Elledge, Stephen J.
Format: Online
Language:English
Published: Genetics Society of America 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015935/