SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing

SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing

Gain-of-function mutations in the tetrodotoxin (TTX) sensitive voltage-gated sodium channel (Nav) Nav1.7 have been identified as a key mechanism underlying chronic pain in inherited erythromelalgia. Mutations in TTX resistant channels, such as Nav1.8 or Nav1.9, were recently connected with inherited...

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Bibliographic Details
Main Authors: Kist, Andreas M., Sagafos, Dagrun, Rush, Anthony M., Neacsu, Cristian, Eberhardt, Esther, Schmidt, Roland, Lunden, Lars Kristian, Ørstavik, Kristin, Kaluza, Luisa, Meents, Jannis, Zhang, Zhiping, Carr, Thomas Hedley, Salter, Hugh, Malinowsky, David, Wollberg, Patrik, Krupp, Johannes, Kleggetveit, Inge Petter, Schmelz, Martin, Jørum, Ellen, Lampert, Angelika, Namer, Barbara
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012686/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012686/

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