Second-generation inhibitors of Bruton tyrosine kinase

Second-generation inhibitors of Bruton tyrosine kinase

Bruton tyrosine kinase (BTK) is a critical effector molecule for B cell development and plays a major role in lymphoma genesis. Ibrutinib is the first-generation BTK inhibitor. Ibrutinib has off-target effects on EGFR, ITK, and Tec family kinases, which explains the untoward effects of ibrutinib. Re...

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Bibliographic Details
Main Authors: Wu, Jingjing, Liu, Christina, Tsui, Stella T., Liu, Delong
Format: Online
Language:English
Published: BioMed Central 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010774/

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