Bringing next‐generation diagnostics to the clinic through synthetic biology
The promise for real precision medicine is contingent on innovative technological solutions to diagnosis and therapy. In the post‐genomic era, rational and systematic approaches to biological design could provide new ways to dynamically probe, monitor, and interface human pathophysiology. Emerging a...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
John Wiley and Sons Inc.
2016
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009805/ |
| id |
pubmed-5009805 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-50098052016-11-14 Bringing next‐generation diagnostics to the clinic through synthetic biology Courbet, Alexis Renard, Eric Molina, Franck Commentary The promise for real precision medicine is contingent on innovative technological solutions to diagnosis and therapy. In the post‐genomic era, rational and systematic approaches to biological design could provide new ways to dynamically probe, monitor, and interface human pathophysiology. Emerging as a mature field increasingly transitioning to the clinics, synthetic biology integrates engineering principles to build sensors, control circuits, and actuators within the biological substrate according to clinical specifications. A particularly tantalizing goal is to develop novel versatile, programmable and autonomous diagnostic devices intertwined with therapy and personalized for the patient to get closest, finest, and most comprehensive diagnostic information and medical procedures. Here, we discuss how synthetic biology could be preparing the future of medicine, supporting and speeding up the development of diagnostics with novel capabilities to bring direct improvement from the clinical laboratory to the patient, while addressing healthcare evolution and global health concerns. John Wiley and Sons Inc. 2016-07-11 2016-09 /pmc/articles/PMC5009805/ /pubmed/27402339 http://dx.doi.org/10.15252/emmm.201606541 Text en © 2016 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the Creative Commons Attribution 4.0 (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Courbet, Alexis Renard, Eric Molina, Franck |
| spellingShingle |
Courbet, Alexis Renard, Eric Molina, Franck Bringing next‐generation diagnostics to the clinic through synthetic biology |
| author_facet |
Courbet, Alexis Renard, Eric Molina, Franck |
| author_sort |
Courbet, Alexis |
| title |
Bringing next‐generation diagnostics to the clinic through synthetic biology |
| title_short |
Bringing next‐generation diagnostics to the clinic through synthetic biology |
| title_full |
Bringing next‐generation diagnostics to the clinic through synthetic biology |
| title_fullStr |
Bringing next‐generation diagnostics to the clinic through synthetic biology |
| title_full_unstemmed |
Bringing next‐generation diagnostics to the clinic through synthetic biology |
| title_sort |
bringing next‐generation diagnostics to the clinic through synthetic biology |
| description |
The promise for real precision medicine is contingent on innovative technological solutions to diagnosis and therapy. In the post‐genomic era, rational and systematic approaches to biological design could provide new ways to dynamically probe, monitor, and interface human pathophysiology. Emerging as a mature field increasingly transitioning to the clinics, synthetic biology integrates engineering principles to build sensors, control circuits, and actuators within the biological substrate according to clinical specifications. A particularly tantalizing goal is to develop novel versatile, programmable and autonomous diagnostic devices intertwined with therapy and personalized for the patient to get closest, finest, and most comprehensive diagnostic information and medical procedures. Here, we discuss how synthetic biology could be preparing the future of medicine, supporting and speeding up the development of diagnostics with novel capabilities to bring direct improvement from the clinical laboratory to the patient, while addressing healthcare evolution and global health concerns. |
| publisher |
John Wiley and Sons Inc. |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009805/ |
| _version_ |
1613642364531769344 |