NOTCH1 mediates a switch between two distinct secretomes during senescence

NOTCH1 mediates a switch between two distinct secretomes during senescence

Senescence, a persistent form of cell cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced senescence (OIS) is accompanied by a dynamic fluctuation of NOTCH1 activity, wh...

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Bibliographic Details
Main Authors: Hoare, Matthew, Ito, Yoko, Kang, Tae-Won, Weekes, Michael P., Matheson, Nicholas J., Patten, Daniel A., Shetty, Shishir, Parry, Aled J., Menon, Suraj, Salama, Rafik, Antrobus, Robin, Tomimatsu, Kosuke, Howat, William, Lehner, Paul J., Zender, Lars, Narita, Masashi
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008465/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008465/

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