Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo

Burkholderia cenocepacia, an opportunistic respiratory pathogen particularly relevant for cystic fibrosis patients, is difficult to eradicate due to its high level of resistance to most clinically relevant antimicrobials. Consequently, the discovery of new antimicrobials as well as molecules capable...

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Bibliographic Details
Main Authors: Scoffone, Viola C., Chiarelli, Laurent R., Makarov, Vadim, Brackman, Gilles, Israyilova, Aygun, Azzalin, Alberto, Forneris, Federico, Riabova, Olga, Savina, Svetlana, Coenye, Tom, Riccardi, Giovanna, Buroni, Silvia
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007513/