Glucagon regulates hepatic lipid metabolism via cAMP and Insig-2 signaling: implication for the pathogenesis of hypertriglyceridemia and hepatic steatosis

Glucagon regulates hepatic lipid metabolism via cAMP and Insig-2 signaling: implication for the pathogenesis of hypertriglyceridemia and hepatic steatosis

Insulin induced gene-2 (Insig-2) is an ER-resident protein that inhibits the activation of sterol regulatory element-binding proteins (SREBPs). However, cellular factors that regulate Insig-2 expression have not yet been identified. Here we reported that cyclic AMP-responsive element-binding protein...

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Bibliographic Details
Main Authors: Wang, Hai, Zhao, Miaoyun, Sud, Neetu, Christian, Patricia, Shen, Jing, Song, Yongyan, Pashaj, Anjeza, Zhang, Kezhong, Carr, Timothy, Su, Qiaozhu
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007496/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007496/

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