The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells

The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells

Mutations of isocitrate dehydrogenase 1 (IDH1) and IDH2 in acute myeloid leukemia (AML) cells produce the oncometabolite R-2-hydroxyglutarate (R-2HG) to induce epigenetic alteration and block hematopoietic differentiation. However, the effect of R-2HG released by IDH-mutated AML cells on the bone ma...

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Bibliographic Details
Main Authors: Chen, Jing-Yi, Lai, You-Syuan, Tsai, Hui-Jen, Kuo, Cheng-Chin, Yen, B. Linju, Yeh, Su-Peng, Sun, H. Sunny, Hung, Wen-Chun
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006242/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006242/

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