Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study

COPD is the third leading cause of death in the world and its global burden is predicted to increase further. Even though the prevalence of COPD is well studied, only few studies examined the incidence of COPD in a prospective and standardized manner. In a prospective population-based cohort study (...

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Main Authors:	Terzikhan, Natalie, Verhamme, Katia M. C., Hofman, Albert, Stricker, Bruno H., Brusselle, Guy G., Lahousse, Lies
Format:	Online
Language:	English
Published:	Springer Netherlands 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005388/

id	pubmed-5005388
recordtype	oai_dc
spelling	pubmed-50053882016-09-15 Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study Terzikhan, Natalie Verhamme, Katia M. C. Hofman, Albert Stricker, Bruno H. Brusselle, Guy G. Lahousse, Lies Respiratory Diseases COPD is the third leading cause of death in the world and its global burden is predicted to increase further. Even though the prevalence of COPD is well studied, only few studies examined the incidence of COPD in a prospective and standardized manner. In a prospective population-based cohort study (Rotterdam Study) enrolling subjects aged ≥45, COPD was diagnosed based on a pre-bronchodilator obstructive spirometry (FEV1/FVC < 0.70). In absence of an interpretable spirometry within the Rotterdam Study, cases were defined as having COPD diagnosed by a physician on the basis of clinical presentation and obstructive lung function measured by the general practitioner or respiratory physician. Incidence rates were calculated by dividing the number of incident cases by the total number of person years of subjects at risk. In this cohort of 14,619 participants, 1993 subjects with COPD were identified of whom 689 as prevalent ones and 1304 cases as incident ones. The overall incidence rate (IR) of COPD was 8.9/1000 person-years (PY); 95 % Confidence Interval (CI) 8.4–9.4. The IR was higher in males and in smokers. The proportion of female COPD participants without a history of smoking was 27.2 %, while this proportion was 7.3 % in males. The prevalence of COPD in the Rotterdam Study is 4.7 % and the overall incidence is approximately 9/1000 PY, with a higher incidence in males and in smokers. The proportion of never-smokers among female COPD cases is substantial. Springer Netherlands 2016-03-05 2016 /pmc/articles/PMC5005388/ /pubmed/26946425 http://dx.doi.org/10.1007/s10654-016-0132-z Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Terzikhan, Natalie Verhamme, Katia M. C. Hofman, Albert Stricker, Bruno H. Brusselle, Guy G. Lahousse, Lies
spellingShingle	Terzikhan, Natalie Verhamme, Katia M. C. Hofman, Albert Stricker, Bruno H. Brusselle, Guy G. Lahousse, Lies Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study
author_facet	Terzikhan, Natalie Verhamme, Katia M. C. Hofman, Albert Stricker, Bruno H. Brusselle, Guy G. Lahousse, Lies
author_sort	Terzikhan, Natalie
title	Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study
title_short	Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study
title_full	Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study
title_fullStr	Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study
title_full_unstemmed	Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study
title_sort	prevalence and incidence of copd in smokers and non-smokers: the rotterdam study
description	COPD is the third leading cause of death in the world and its global burden is predicted to increase further. Even though the prevalence of COPD is well studied, only few studies examined the incidence of COPD in a prospective and standardized manner. In a prospective population-based cohort study (Rotterdam Study) enrolling subjects aged ≥45, COPD was diagnosed based on a pre-bronchodilator obstructive spirometry (FEV1/FVC < 0.70). In absence of an interpretable spirometry within the Rotterdam Study, cases were defined as having COPD diagnosed by a physician on the basis of clinical presentation and obstructive lung function measured by the general practitioner or respiratory physician. Incidence rates were calculated by dividing the number of incident cases by the total number of person years of subjects at risk. In this cohort of 14,619 participants, 1993 subjects with COPD were identified of whom 689 as prevalent ones and 1304 cases as incident ones. The overall incidence rate (IR) of COPD was 8.9/1000 person-years (PY); 95 % Confidence Interval (CI) 8.4–9.4. The IR was higher in males and in smokers. The proportion of female COPD participants without a history of smoking was 27.2 %, while this proportion was 7.3 % in males. The prevalence of COPD in the Rotterdam Study is 4.7 % and the overall incidence is approximately 9/1000 PY, with a higher incidence in males and in smokers. The proportion of never-smokers among female COPD cases is substantial.
publisher	Springer Netherlands
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005388/
_version_	1613639465319792640

Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study

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