Evaluation of Concurrent Radiation, Temozolomide and ABT-888 Treatment Followed by Maintenance Therapy with Temozolomide and ABT-888 in a Genetically Engineered Glioblastoma Mouse Model

Evaluation of Concurrent Radiation, Temozolomide and ABT-888 Treatment Followed by Maintenance Therapy with Temozolomide and ABT-888 in a Genetically Engineered Glioblastoma Mouse Model

Despite the use of ionizing radiation (IR) and temozolomide (TMZ), outcome for glioblastoma (GBM) patients remains dismal. Poly (ADP-ribose) polymerase (PARP) is important in repair pathways for IR-induced DNA damage and TMZ-induced alkylation at N7-methylguanine and N3-methyldenine. However, optimi...

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Bibliographic Details
Main Authors: Lemasson, Benjamin, Wang, Hanxiao, Galbán, Stefanie, Li, Yinghua, Zhu, Yuan, Heist, Kevin A., Tsein, Christina, Chenevert, Thomas L., Rehemtulla, Alnawaz, Galbán, Craig J., Holland, Eric C., Ross, Brian D.
Format: Online
Language:English
Published: Neoplasia Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005260/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005260/

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