Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs

Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs

The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular organisms. Here, we characterise AEBP2, a known PRC2 co-factor which, in vitro, has been shown to stimulate PRC2 activity. We show that AEBP2 localises specifically to PRC2 target loci, inc...

Full description

Bibliographic Details
Main Authors: Grijzenhout, Anne, Godwin, Jonathan, Koseki, Haruhiko, Gdula, Michal Ryszard, Szumska, Dorota, McGouran, Joanna F., Bhattacharya, Shoumo, Kessler, Benedikt M., Brockdorff, Neil, Cooper, Sarah
Format: Online
Language:English
Published: The Company of Biologists Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004903/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004903/

Similar Items