Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion
How macropinosomes traffic to lysosomes is poorly understood. Dolat and Spiliotis show that septins associate preferentially with mature macropinosomes in a PI(3,5)P2-dependent manner and regulate fluid-phase cargo traffic to lysosomes by promoting macropinosome/endosome fusion.
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004444/ |