Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants

Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants

HtrA2(Omi) protease controls protein quality in mitochondria and plays a major role in apoptosis. Its HtrA2S306A mutant (with the catalytic serine routinely disabled for an X-ray study to avoid self-degradation) is a homotrimer whose subunits contain the serine protease domain (PD) and the regulator...

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Bibliographic Details
Main Authors: Gieldon, Artur, Zurawa-Janicka, Dorota, Jarzab, Miroslaw, Wenta, Tomasz, Golik, Przemyslaw, Dubin, Grzegorz, Lipinska, Barbara, Ciarkowski, Jerzy
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003398/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003398/

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