Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth

The current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underl...

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Main Authors:	Dismukes, Andrew R, Meyer, Vanessa J, Shirtcliff, Elizabeth A, Theall, Katherine P, Esteves, Kyle C, Drury, Stacy S
Format:	Online
Language:	English
Published:	Bioscientifica Ltd 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002957/

id	pubmed-5002957
recordtype	oai_dc
spelling	pubmed-50029572016-08-30 Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth Dismukes, Andrew R Meyer, Vanessa J Shirtcliff, Elizabeth A Theall, Katherine P Esteves, Kyle C Drury, Stacy S Research The current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underlying physiological process that may overlap with TL. One hundred and two participants completed the Trier Social Stressor Test for children (TSST-C). TL was obtained from all youth from buccal swabs on the same day as the TSST-C. Saliva samples from 83 participants were obtained over the course of two additional days to measure waking and diurnal levels of DHEA. DHEA diurnal slope was a robust predictor of TL (B=0.516, P<0.05), while other DHEA values were not significantly associated with TL. This study is one of the first studies to examine basal, diurnal and reactivity measurements of DHEA in youth. Furthermore, this is the first study, to our knowledge, to demonstrate a positive association between DHEA, a putative anti-aging hormone, and TL, an indicator of cellular aging. Bioscientifica Ltd 2016-05-01 /pmc/articles/PMC5002957/ /pubmed/27221260 http://dx.doi.org/10.1530/EC-16-0007 Text en © 2016 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) .
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Dismukes, Andrew R Meyer, Vanessa J Shirtcliff, Elizabeth A Theall, Katherine P Esteves, Kyle C Drury, Stacy S
spellingShingle	Dismukes, Andrew R Meyer, Vanessa J Shirtcliff, Elizabeth A Theall, Katherine P Esteves, Kyle C Drury, Stacy S Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
author_facet	Dismukes, Andrew R Meyer, Vanessa J Shirtcliff, Elizabeth A Theall, Katherine P Esteves, Kyle C Drury, Stacy S
author_sort	Dismukes, Andrew R
title	Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
title_short	Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
title_full	Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
title_fullStr	Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
title_full_unstemmed	Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
title_sort	diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
description	The current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underlying physiological process that may overlap with TL. One hundred and two participants completed the Trier Social Stressor Test for children (TSST-C). TL was obtained from all youth from buccal swabs on the same day as the TSST-C. Saliva samples from 83 participants were obtained over the course of two additional days to measure waking and diurnal levels of DHEA. DHEA diurnal slope was a robust predictor of TL (B=0.516, P<0.05), while other DHEA values were not significantly associated with TL. This study is one of the first studies to examine basal, diurnal and reactivity measurements of DHEA in youth. Furthermore, this is the first study, to our knowledge, to demonstrate a positive association between DHEA, a putative anti-aging hormone, and TL, an indicator of cellular aging.
publisher	Bioscientifica Ltd
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002957/
_version_	1613638075053768704

Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth

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