The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm

The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm

Abdominal aortic aneurysm (AAA) is a vascular condition that causes permanent dilation of the abdominal aorta, which can lead to death due to aortic rupture. The only treatment for AAA is surgical repair, and there is no current drug treatment for AAA. Aortic inflammation, vascular smooth muscle cel...

Full description

Bibliographic Details
Main Authors: Li, Jiaze, Krishna, Smriti Murali, Golledge, Jonathan
Format: Online
Language:English
Published: MDPI 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000709/
id pubmed-5000709
recordtype oai_dc
spelling pubmed-50007092016-09-01 The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm Li, Jiaze Krishna, Smriti Murali Golledge, Jonathan Review Abdominal aortic aneurysm (AAA) is a vascular condition that causes permanent dilation of the abdominal aorta, which can lead to death due to aortic rupture. The only treatment for AAA is surgical repair, and there is no current drug treatment for AAA. Aortic inflammation, vascular smooth muscle cell apoptosis, angiogenesis, oxidative stress and vascular remodeling are implicated in AAA pathogenesis. Kallistatin is a serine proteinase inhibitor, which has been shown to have a variety of functions, potentially relevant in AAA pathogenesis. Kallistatin has been reported to have inhibitory effects on tumor necrosis factor alpha (TNF-α) signaling induced oxidative stress and apoptosis. Kallistatin also inhibits vascular endothelial growth factor (VEGF) and Wnt canonical signaling, which promote inflammation, angiogenesis, and vascular remodeling in various pre-clinical experimental models. This review explores the potential protective role of kallistatin in AAA pathogenesis. MDPI 2016-08-11 /pmc/articles/PMC5000709/ /pubmed/27529213 http://dx.doi.org/10.3390/ijms17081312 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Li, Jiaze
Krishna, Smriti Murali
Golledge, Jonathan
spellingShingle Li, Jiaze
Krishna, Smriti Murali
Golledge, Jonathan
The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm
author_facet Li, Jiaze
Krishna, Smriti Murali
Golledge, Jonathan
author_sort Li, Jiaze
title The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm
title_short The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm
title_full The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm
title_fullStr The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm
title_full_unstemmed The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm
title_sort potential role of kallistatin in the development of abdominal aortic aneurysm
description Abdominal aortic aneurysm (AAA) is a vascular condition that causes permanent dilation of the abdominal aorta, which can lead to death due to aortic rupture. The only treatment for AAA is surgical repair, and there is no current drug treatment for AAA. Aortic inflammation, vascular smooth muscle cell apoptosis, angiogenesis, oxidative stress and vascular remodeling are implicated in AAA pathogenesis. Kallistatin is a serine proteinase inhibitor, which has been shown to have a variety of functions, potentially relevant in AAA pathogenesis. Kallistatin has been reported to have inhibitory effects on tumor necrosis factor alpha (TNF-α) signaling induced oxidative stress and apoptosis. Kallistatin also inhibits vascular endothelial growth factor (VEGF) and Wnt canonical signaling, which promote inflammation, angiogenesis, and vascular remodeling in various pre-clinical experimental models. This review explores the potential protective role of kallistatin in AAA pathogenesis.
publisher MDPI
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000709/
_version_ 1613636998008930304

Similar Items