Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism

Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism

Chronic lymphocytic leukemia (CLL) is an adult B cell malignancy. Genome-wide association studies show that variation at 15q15.1 influences CLL risk. We deciphered the causal variant at 15q15.1 and the mechanism by which it influences tumorigenesis. We imputed all possible genotypes across the locus...

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Bibliographic Details
Main Authors: Kandaswamy, Radhika, Sava, Georgina P., Speedy, Helen E., Beà, Sílvia, Martín-Subero, José I., Studd, James B., Migliorini, Gabriele, Law, Philip J., Puente, Xose S., Martín-García, David, Salaverria, Itziar, Gutiérrez-Abril, Jesús, López-Otín, Carlos, Catovsky, Daniel, Allan, James M., Campo, Elías, Houlston, Richard S.
Format: Online
Language:English
Published: Cell Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999417/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999417/

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