Differential ERK1/2 Signaling and Hypertrophic Response to Endothelin-1 in Cardiomyocytes from SHR and Wistar-Kyoto Rats: A Potential Target for Combination Therapy of Hypertension

Extracellular signal regulated kinase½ (ERK1/2) signaling is critical to endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy. This study was to investigate ERK1/2 signaling and hypertrophic response to ET-1 stimulation in cardiomyocytes (CMs) from spontaneous hypertensive rats (SHR) and normotensi...

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Bibliographic Details
Main Authors: Zhu, Li-an, Fang, Ning-yuan, Gao, Ping-jin, Jin, Xian, Wang, Hai-ya, Liu, Zhenguo
Format: Online
Language:English
Published: Bentham Science Publishers 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997939/