The emergence of superstructural order in insulin amyloid fibrils upon multiple rounds of self-seeding

Typically, elongation of an amyloid fibril entails passing conformational details of the mother seed to daughter generations of fibrils with high fidelity. There are, however, several factors that can potentially prevent such transgenerational structural imprinting from perpetuating, for example het...

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Bibliographic Details
Main Authors: Surmacz-Chwedoruk, Weronika, Babenko, Viktoria, Dec, Robert, Szymczak, Piotr, Dzwolak, Wojciech
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997315/