Staphylococcus aureus vaccines: Deviating from the carol
Staphylococcus aureus, a commensal of the human nasopharynx and skin, also causes invasive disease, most frequently skin and soft tissue infections. Invasive disease caused by drug-resistant strains, designated MRSA (methicillin-resistant S. aureus), is associated with failure of antibiotic therapy...
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The Rockefeller University Press
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995089/ |
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pubmed-4995089 |
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pubmed-49950892017-02-22 Staphylococcus aureus vaccines: Deviating from the carol Missiakas, Dominique Schneewind, Olaf Reviews Staphylococcus aureus, a commensal of the human nasopharynx and skin, also causes invasive disease, most frequently skin and soft tissue infections. Invasive disease caused by drug-resistant strains, designated MRSA (methicillin-resistant S. aureus), is associated with failure of antibiotic therapy and elevated mortality. Here we review polysaccharide-conjugate and subunit vaccines that were designed to prevent S. aureus infection in patients at risk of bacteremia or surgical wound infection but failed to reach their clinical endpoints. We also discuss vaccines with ongoing trials for combinations of polysaccharide-conjugates and subunits. S. aureus colonization and invasive disease are not associated with the development of protective immune responses, which is attributable to a large spectrum of immune evasion factors. Two evasive strategies, assembly of protective fibrin shields via coagulases and protein A–mediated B cell superantigen activity, are discussed as possible vaccine targets. Although correlates for protective immunity are not yet known, opsonophagocytic killing of staphylococci by phagocytic cells offers opportunities to establish such criteria. The Rockefeller University Press 2016-08-22 /pmc/articles/PMC4995089/ /pubmed/27526714 http://dx.doi.org/10.1084/jem.20160569 Text en © 2016 Missiakas and Schneewind This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Missiakas, Dominique Schneewind, Olaf |
| spellingShingle |
Missiakas, Dominique Schneewind, Olaf Staphylococcus aureus vaccines: Deviating from the carol |
| author_facet |
Missiakas, Dominique Schneewind, Olaf |
| author_sort |
Missiakas, Dominique |
| title |
Staphylococcus aureus vaccines: Deviating from the carol |
| title_short |
Staphylococcus aureus vaccines: Deviating from the carol |
| title_full |
Staphylococcus aureus vaccines: Deviating from the carol |
| title_fullStr |
Staphylococcus aureus vaccines: Deviating from the carol |
| title_full_unstemmed |
Staphylococcus aureus vaccines: Deviating from the carol |
| title_sort |
staphylococcus aureus vaccines: deviating from the carol |
| description |
Staphylococcus aureus, a commensal of the human nasopharynx and skin, also causes invasive disease, most frequently skin and soft tissue infections. Invasive disease caused by drug-resistant strains, designated MRSA (methicillin-resistant S. aureus), is associated with failure of antibiotic therapy and elevated mortality. Here we review polysaccharide-conjugate and subunit vaccines that were designed to prevent S. aureus infection in patients at risk of bacteremia or surgical wound infection but failed to reach their clinical endpoints. We also discuss vaccines with ongoing trials for combinations of polysaccharide-conjugates and subunits. S. aureus colonization and invasive disease are not associated with the development of protective immune responses, which is attributable to a large spectrum of immune evasion factors. Two evasive strategies, assembly of protective fibrin shields via coagulases and protein A–mediated B cell superantigen activity, are discussed as possible vaccine targets. Although correlates for protective immunity are not yet known, opsonophagocytic killing of staphylococci by phagocytic cells offers opportunities to establish such criteria. |
| publisher |
The Rockefeller University Press |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995089/ |
| _version_ |
1613633104917823488 |