The importance of L1 ORF2p cryptic sequence to ORF2p fragment-mediated cytotoxicity
The Long Interspersed Element 1 (LINE1 or L1) ORF2 protein (ORF2p) can cause DNA damage through the activity of its endonuclease domain (EN). The DNA double-strand breaks (DSB) introduced by the ORF2p EN have the potential to be mutagenic. Previously, our lab has shown that ORF2p fragments containin...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Taylor & Francis
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993571/ |