Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1

Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1

The activating NK-cell receptor KIR3DS1 has been implicated in the outcome of various human diseases, including delayed HIV-1 disease progression, yet a ligand that accounts for its biological effects remained unknown. We screened 100 HLA-I proteins and found that KIR3DS1 binds HLA-F, which was vali...

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Bibliographic Details
Main Authors: Garcia-Beltran, Wilfredo F., Hölzemer, Angelique, Martrus, Gloria, Chung, Amy W., Pacheco, Yovana, Simoneau, Camille R., Rucevic, Marijana, Lamothe-Molina, Pedro A., Pertel, Thomas, Kim, Tae-Eun, Dugan, Haley, Alter, Galit, Dechanet-Merville, Julie, Jost, Stephanie, Carrington, Mary, Altfeld, Marcus
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992421/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992421/

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