The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

Epithelial cells that lose attachment to the extracellular matrix undergo a specialized form of apoptosis called anoikis. Here, using large-scale RNA interference (RNAi) screening, we find that KDM3A, a histone H3 lysine 9 (H3K9) mono- and di-demethylase, plays a pivotal role in anoikis induction. I...

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Bibliographic Details
Main Authors: Pedanou, Victoria E, Gobeil, Stéphane, Tabariès, Sébastien, Simone, Tessa M, Zhu, Lihua Julie, Siegel, Peter M, Green, Michael R
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991936/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991936/

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