Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1α via the PI3K/AKT/mTOR pathway

It has been reported that there are multiple mechanisms by which bufalin could exert its antimetastatic effect. HIF-1α has been reported to be involved in tumor migration and invasion by regulating EMT. However, it is not known whether bufalin could exert the antimetastatic effect by modulating HIF-...

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Bibliographic Details
Main Authors: Wang, Haiyong, Zhang, Chenyue, Xu, Litao, Zang, Kun, Ning, Zhouyu, Jiang, Feng, Chi, Huiying, Zhu, Xiaoyan, Meng, Zhiqiang
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991447/