Effector proteins support the asymmetric apportioning of Salmonella during cytokinesis

Salmonella-infected cells are characterized by the presence of intra-cellular membranous tubules that emerge from bacterial vacuoles and extend along microtubules. The formation of Salmonella-induced tubules depends on the Salmonella pathogenicity island 2-encoded type III secretion system (T3SS-2)...

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Main Authors:	Zhao, Yaya, Gorvel, Jean-Pierre, Méresse, Stéphane
Format:	Online
Language:	English
Published:	Taylor & Francis 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991364/

id	pubmed-4991364
recordtype	oai_dc
spelling	pubmed-49913642016-08-31 Effector proteins support the asymmetric apportioning of Salmonella during cytokinesis Zhao, Yaya Gorvel, Jean-Pierre Méresse, Stéphane Research Paper Salmonella-infected cells are characterized by the presence of intra-cellular membranous tubules that emerge from bacterial vacuoles and extend along microtubules. The formation of Salmonella-induced tubules depends on the Salmonella pathogenicity island 2-encoded type III secretion system (T3SS-2) that translocates bacterial effector proteins inside host cells. Effector proteins have enzymatic activities or allow for hijacking of cellular functions. The role of Salmonella-induced tubules in virulence remains unclear but their absence is correlated with virulence defects. This study describes the presence of inter-cellular tubules that arise between daughter cells during cytokinesis. Inter-cellular tubules connect bacterial vacuoles originally present in the parent cell and that have been apportioned between daughters. Their formation requires a functional T3SS-2 and effector proteins. Our data establish a correlation between the formation of inter-cellular tubules and the asymmetric distribution of bacterial vacuoles in daughters. Thus, by manipulating the distribution of bacteria in cytokinetic cells, Salmonella T3SS-2 effector proteins may increase bacterial spreading and the systemic character of the infection. Taylor & Francis 2016-04-05 /pmc/articles/PMC4991364/ /pubmed/27046257 http://dx.doi.org/10.1080/21505594.2016.1173298 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhao, Yaya Gorvel, Jean-Pierre Méresse, Stéphane
spellingShingle	Zhao, Yaya Gorvel, Jean-Pierre Méresse, Stéphane Effector proteins support the asymmetric apportioning of Salmonella during cytokinesis
author_facet	Zhao, Yaya Gorvel, Jean-Pierre Méresse, Stéphane
author_sort	Zhao, Yaya
title	Effector proteins support the asymmetric apportioning of Salmonella during cytokinesis
title_short	Effector proteins support the asymmetric apportioning of Salmonella during cytokinesis
title_full	Effector proteins support the asymmetric apportioning of Salmonella during cytokinesis
title_fullStr	Effector proteins support the asymmetric apportioning of Salmonella during cytokinesis
title_full_unstemmed	Effector proteins support the asymmetric apportioning of Salmonella during cytokinesis
title_sort	effector proteins support the asymmetric apportioning of salmonella during cytokinesis
description	Salmonella-infected cells are characterized by the presence of intra-cellular membranous tubules that emerge from bacterial vacuoles and extend along microtubules. The formation of Salmonella-induced tubules depends on the Salmonella pathogenicity island 2-encoded type III secretion system (T3SS-2) that translocates bacterial effector proteins inside host cells. Effector proteins have enzymatic activities or allow for hijacking of cellular functions. The role of Salmonella-induced tubules in virulence remains unclear but their absence is correlated with virulence defects. This study describes the presence of inter-cellular tubules that arise between daughter cells during cytokinesis. Inter-cellular tubules connect bacterial vacuoles originally present in the parent cell and that have been apportioned between daughters. Their formation requires a functional T3SS-2 and effector proteins. Our data establish a correlation between the formation of inter-cellular tubules and the asymmetric distribution of bacterial vacuoles in daughters. Thus, by manipulating the distribution of bacteria in cytokinetic cells, Salmonella T3SS-2 effector proteins may increase bacterial spreading and the systemic character of the infection.
publisher	Taylor & Francis
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991364/
_version_	1613630777489096704

Effector proteins support the asymmetric apportioning of Salmonella during cytokinesis

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