The heterogeneity of store-operated calcium entry in melanoma
Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry (SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and fu...
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| Format: | Online |
| Language: | English |
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2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991353/ |
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pubmed-49913532016-08-19 The heterogeneity of store-operated calcium entry in melanoma Hooper, Robert Zaidi, M. Raza Soboloff, Jonathan Article Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry (SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIM and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIM, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease. 2016-07-14 2016-08 /pmc/articles/PMC4991353/ /pubmed/27417567 http://dx.doi.org/10.1007/s11427-016-5087-5 Text en http://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Hooper, Robert Zaidi, M. Raza Soboloff, Jonathan |
| spellingShingle |
Hooper, Robert Zaidi, M. Raza Soboloff, Jonathan The heterogeneity of store-operated calcium entry in melanoma |
| author_facet |
Hooper, Robert Zaidi, M. Raza Soboloff, Jonathan |
| author_sort |
Hooper, Robert |
| title |
The heterogeneity of store-operated calcium entry in melanoma |
| title_short |
The heterogeneity of store-operated calcium entry in melanoma |
| title_full |
The heterogeneity of store-operated calcium entry in melanoma |
| title_fullStr |
The heterogeneity of store-operated calcium entry in melanoma |
| title_full_unstemmed |
The heterogeneity of store-operated calcium entry in melanoma |
| title_sort |
heterogeneity of store-operated calcium entry in melanoma |
| description |
Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry (SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIM and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIM, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease. |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991353/ |
| _version_ |
1613630774900162560 |